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Oklahoma State University

Mass Spectrometry/Proteomics

Protein scientists use the new Orbitrap tandem mass spectrometer for high-throughput proteomics research, which is the study of large sets of proteins simultaneously in single-pass experiments. Using this strategy, the scientists dissect the structural, metabolic and regulatory machinery of cells and tissues. This is a powerful strategy for conducting fundamental research and for finding biomarkers of health, disease and vigor. The instrument is also used to study the biochemistry of individual proteins and various small molecules. This flagship instrument runs almost 24/7, and an overnight run often generates 500 megabytes of data.

The Typhoon fluorescence scanner is an instrument available for researchers using fluorescent molecules to image: tissues, one- and two-dimension separations of proteins and nucleic acids, and radioactivity.Its three lasers and numerous light wavelength filters allow researchers to utilize specific colors of light in order to take advantage a whole new generation of fluorescent biomolecular probes.